The medication is taken by mouth. Loperamide was first made in 1969 and used medically in 1976. Recent studies suggest that loperamide is more katzung pharmacology 12th edition pdf free download and has lower neural side effects.
The most frequent symptoms of loperamide overdose are drowsiness, vomiting and abdominal pain or burning. If abdominal distension is noted, therapy with loperamide should be discontinued. The use of loperamide in children under 2 years is not recommended. A review of loperamide in children under 12 years old, and found that serious adverse events occurred only in children under 3 years old. The study reported that the use of loperamide should be contraindicated in children under 3 years old, systemically ill, malnourished, moderately dehydrated, or have bloody diarrhea. One controlled, prospective study of 89 women exposed to loperamide during the first trimester showed no increased risk of malformations. This, however, was only one study with a small sample size.
Loperamide can be present in breast milk, and is not recommended for breast feeding mothers. Loperamide is capable of decreasing the absorption of some other drugs. Loperamide is an anti-diarrheal agent which decreases intestinal movement. As such, when combined with other antimotility drugs, there is an increased risk of constipation.