Physical chemistry for the biosciences pdf chang-99m used for labelling biomolecules for molecular imaging. Developments and enhancements to improve its efficacy and versatility, including applications beyond Tc-99m labelling, include designs to allow site specificity, availability of amino acid building blocks, improved protecting groups, and a varied choice of co-ligands.
In this review, these enhancements are summarised, along with an assessment of the opportunities afforded and problems posed by the use of HYNIC, a discussion of its coordination mode, and the prospects for improving its use and overcoming some of the limitations. In summary, HYNIC represents a well-established way to exploit the highly reactive hydrazine group, to generate bioconjugate chemistry with a degree of bioorthogonality offering the possibility for highly efficient and site specific modification of biomolecules for imaging. Tc-99m is summarised, along with an assessment of the opportunities and problems it presents, a discussion of its coordination mode, and the prospects for improving its use and overcoming some of the limitations. Check if you have access through your login credentials or your institution. He joined the Division of Imaging Sciences at King’s College London in October 2008. Radiopharmaceutics and PET Radiochemistry he started a Ph.
Her final year project was under supervision of Prof. Lindequist in natural product isolation. HYNIC coordination chemistry at University of Kent in 2008. After postdoctoral positions at the University of North Wales, and Imperial College, London, and a faculty appointment at Kings College, London, Dr.